A team at Chuo University, led by Professor Hiroaki Suzuki, has pioneered a microfluidic process to mass‑produce uniform artificial cells (lipid vesicles) containing model nuclei—miniature DNA condensates—with remarkable precision
Using a microfluidic “production line,” the researchers encapsulated DNA nanostars and salts inside cell-sized liposomes. Controlled osmotic volume changes within each vesicle triggered the formation of uniform nuclei-like structures—no heat-induced damage required Crucially, these artificial nuclei successfully expressed green fluorescent protein (GFP), demonstrating act ive protein synthesis
This advance brings artificial cells closer to mimicking living eukaryotic cells, with potential applications in molecular sensing, environmental response, and future cell-replacement biotechnology.
The findings were published June 16, 2025, in JACS Au
